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Artigos Publicados
- 2026
Volonte, C.; Hu, G.; Shaw, C.; Viegas Jr., C.; et al. Neuroprotection Beyond Neurons: Integrated Biomarker-Based and Astroglia- or Microglia-Targeted Approaches to Combat Neurodegenerative Diseases. Exploration of Neuroprotective Therapy, v. 6, p. 1004136, 2026.
Invencio, C. G. G.; Lontra, A. C. P.; Paiva, J. P. B.; et al. Pharmacological characterization of the anti-nociceptive and anti-inflammatory effects of new CBD-based terpenyl-N-acyl-aryl-hydrazone analogues. Biomedicine & Pharmacotherapy, v. 194, p. 118925, 2026.
- 2025
Ureña, M. J. E.; Katchborian-Neto, A.; et al. Simarouba berteroana Krug & Urb. extracts and fractions possess anthelmintic activity against multidrug-resistant Haemonchus contortus. Veterinary Sciences, v. 12, p. 90–117, 2025.
Souza, M. L.; Paiva, J. P. B.; et al. Design, synthesis, and evaluation of antinociceptive properties of novel CBD-based terpene-cinnamoyl-acyl-hydrazone analogues. Pharmaceuticals, v. 18, p. 755, 2025.
Victor, M. M.; Ramos, G. S.; et al. Design, synthesis, and in vitro evaluation of the leishmanicidal activity of new aromatic symmetrical 1,4-disubstituted 1,2,3-bistriazoles. ACS Omega, 2025.
Franco, G. R. R.; Silva, I. M. F.; et al. New cannabidiol structure-related terpene N-acyl-hydrazones with potent antinociceptive and anti-inflammatory activity. Future Medicinal Chemistry, 2025.
Fonseca, R.; Louzano, Y. S.; et al. Curcumin-like compound inhibits proliferation of adenocarcinoma cells by inducing cell cycle arrest and senescence. Pharmaceuticals, v. 18, p. 914, 2025.
Ribeiro, L. V.; Massuda, L. E.; Gontijo, V. S.; Viegas Jr., C. Monoamine oxidase inhibitors in drug discovery against Parkinson’s disease: an update. Pharmaceuticals, v. 18, p. 1526–1605, 2025.
Franco, G. R. R.; Gontijo, V. S.; et al. Novel multifunctional cannabidiol-based analogues with in silico, in vitro, and in vivo anti-SARS-CoV-2 effect. Pharmaceuticals, v. 18, p. 1565, 2025.
Reis, V. E. N.; Franco, G. R. R.; et al. Evaluation of novel selective MAO-B inhibitors using immobilized enzymes on magnetic beads. Journal of Pharmaceutical and Biomedical Analysis, v. 268, p. 117200, 2025.
Baptistella, M. M.; Siqueira, A. P.; et al. Resveratrol-curcumin hybrid selectively induces chromosomal abnormalities and apoptosis in colon adenocarcinoma cells. Antioxidants, v. 14, p. 1367, 2025.
- 2024
Souza, A. A.; Viegas, F. P. D.; et al. Antinociceptive effect of Dillenia indica mediated by opioid and cannabinoid systems. Chemistry & Biodiversity, v. 21, p. 1–14, 2024.
Duarte Filho, L. A. M. S.; Leal, C. E. Y.; et al. Identification of peptide inhibitors of coronavirus 3CL protease from Fucus ceranoides. Marine Drugs, v. 22, p. 244, 2024.
Silva, I. M. F.; Franco, G. R. R.; Gontijo, V. S.; Viegas Jr., C. Protein kinases as therapeutic targets for Alzheimer’s disease: a brief review. Exploration of Neuroprotective Therapy, v. 4, p. 411–441, 2024.
Souza, M.; Franco, G. R. R.; et al. Analogues and derivatives of cannabidiol: pharmacological insights and recent efforts. Journal of the Brazilian Chemical Society, v. 35, 2024.
Freitas Silva, M.; Ortiz, C. J. C.; et al. Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids for Parkinson’s disease. Bioorganic Chemistry, v. 150, p. 107587, 2024.
- 2023
Ernesto, J. T.; Damasio, C. M.; et al. The role of the microbiota–gut–brain axis in neurodegenerative diseases. Exploration of Neuroprotective Therapy, v. 3, p. 71–89, 2023.
Pressete, C. G.; Viegas, F. P. D.; et al. Piperine–chlorogenic acid hybrid inhibits melanoma cell proliferation. Pharmaceuticals, v. 16, p. 145, 2023.
Baptistella, M. M.; Assunção, R. R. S.; et al. Synthetic resveratrol–curcumin hybrid exhibits chemopreventive effects. Journal of Pharmacy and Pharmacology, v. 76, p. 479–488, 2023.
Miguel de Oliveira, C.; Horvath, R.; et al. PQM-75: an N-benzyl-piperidine acyl-hydrazone derivative with antitumoral activity. Revista Virtual de Química, v. 15, p. 464–471, 2023.
Espino Ureña, M. J.; Katchborian-Neto, A.; et al. Chemical composition and anthelmintic activity of Lippia dominguensis essential oil. Chemistry & Biodiversity, v. 20, 2023.
- 2022
VAZ, S. M.; et al. Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s disease Bioorganic & Medicinal Chemistry, v. 71, p. 116952, 2022.
VIEGAS, F. P. D.; et al. Curcumin, resveratrol and cannabidiol as natural prototypes in neuroprotective drug design. Current Neuropharmacology, v. 20, p. 1297–1328, 2022.
CRISTANCHO ORTIZ, C. J.; et al. Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation. RSC Medicinal Chemistry, v. 13, p. 568–584, 2022.
2021
ETIENNE, R.; VIEGAS JR., C. Aspectos fisiopatológicos da inflamação e o planejamento de fármacos. Revista Virtual de Química, v. 13, p. 167–191, 2021.
DE SOUZA, A. A.; et al. Semysinthetic biflavonoid Morelloflavone-7,4′,7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin. Biochimica et Biophysica Acta, v. 1865, 2021.
2020
GONTIJO, V. S.; et al. Molecular hybridization as a tool in multi-target drug design for neurodegenerative diseases. Current Neuropharmacology, v. 18, p. 348–407, 2020.
SILVA, M. F.; et al. Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease.
Molecules, v. 25, 2020.
MAKHOBA, X. H.; et al. Potential Impact of multi-target drug approaches in complex diseases. Drug Design, Development and Therapy, v. 14, 2020.
PIROLLA, N. F. F.; et al. Alzheimer’s Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches. Current Drug Targets, v. 22, 2020.
ORTIZ, C. J. C.; et al. Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases. Neurochemical Research, v. 45, 2020.
VIEGAS, C.; FRAGA, C. A. M.; et al. Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases? Frontiers in Pharmacology, v. 11, 2020.
FRANCO, G. R. R.; VIEGAS, C. Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases. Current Neuropharmacology, v. 18, 2020.
2019
MORRONI, F.; SITA, G.; GRAZIOSI, A.; et al. PQM130, a novel feruloyl-donepezil hybrid compound, effectively ameliorates the cognitive impairments and pathology in a mouse model of Alzheimer’s disease. Frontiers in Pharmacology, v. 10, 2019.
CÉSAR DA SILVA, R.; VEIGA, F.; VILELA, F. C.; et al. Design, synthesis and pharmacological evaluation of novel anti-inflammatory and analgesic O-benzyloxime compounds derived from natural eugenol. Letters in Drug Design & Discovery, v. 16, p. 1157–1166, 2019.
BELLOZI, P. M. Q.; CAMPOS, A. C.; VIEGAS, F. P. D.; et al. New multifunctional AChE inhibitor drug prototypes protect against Aβ-induced memory deficit. Neurological Sciences, v. 2, p. 451–455, 2019.
2018
SILVA, M. F.; DIAS, K. S. T.; GONTIJO, V. S.; et al. Multi-target directed drugs as a modern approach for drug design towards Alzheimer’s disease: an update. Current Medicinal Chemistry, v. 25, p. 3491–3525, 2018.
SANTOS, N. M.; PEREIRA, N. C.; ALBUQUERQUE, A. P. S.; et al. 3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain mediated by opioid system. Biomedicine & Pharmacotherapy, v. 99, p. 492–498, 2018.
VIEGAS, F. P. D.; SILVA, M. F.; ROCHA, M. D.; et al. Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids. European Journal of Medicinal Chemistry, v. 147, p. 48–65, 2018.
DE FREITAS SILVA, M.; COELHO, L. F.; GUIRELLI, I. M.; et al. Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells Toxicology in Vitro, v. 50, p. 75–85, 2018.
FREITAS, T. R.; DANUELLO, A.; VIEGAS JR., C.; et al. Mass spectrometry for characterization of homologous piperidine alkaloids as acetylcholinesterase inhibitors. Rapid Communications in Mass Spectrometry, v. 33, p. 1303–1310, 2018.
DE FREITAS SILVA, M.; PRUCCOLI, L.; MORRONI, F.; et al. The Keap1/Nrf2-ARE pathway as a pharmacological target for chalcones. Molecules, v. 23, 2018.
SILVA, N. C.; CARVALHO, R. R.; CUSINATO, M.; et al. Promising synergistic activity of fluconazole with bioactive Guttiferone-A and derivatives against non-albicans Candida species Journal de Mycologie Médicale, 2018.
LACERDA, R. B. M.; FREITAS, T. R.; MARTINS, M. M.; et al. Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis Bioorganic & Medicinal Chemistry, v. 26, p. 5816–5823, 2018.
VICTOR, M. M.; FARIAS, R. R.; DA SILVA, D. L.; et al. Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions Medicinal Chemistry, v. 14, p. 400–408, 2018.
2017
COLOMBO, F. A.; REIS, R. A.; NUNES, J. B.; et al. In Vivo Evaluation of Leishmanicidal Activity of Benzophenone Derivatives by qPCR Medicinal Chemistry: Current Research, v. 7, p. 890–893, 2017.
SILVA, G. A. F.; ORTEGA, M. M.; BARIONIS, M. A.; et al. A novel ruthenium complex inhibits ERK activation in A549 cells. Toxicology in Vitro, v. 44, p. 382–391, 2017.
FRANCO, G. R. R.; VIEGAS JR., C. The contribution of cannabidiol and synthetic analogues in neuropsychiatric drug design. Revista Virtual de Química, v. 9, p. 1773–1798, 2017.
FREITAS, P.; CASTILHO, T. E.; ALMEIDA, L.; et al. In silico study of benzophenone derivatives against Trypanosoma cruzi and Leishmania. Journal of the Brazilian Chemical Society, 2017.
DIAS, K. S. T.; DE PAULA, C. T.; DOS SANTOS, T.; et al. Design, synthesis and evaluation of novel feruloyl-donepezil hybrids. European Journal of Medicinal Chemistry, v. 130, p. 440–457, 2017.
TAROZZI, A.; DIAS, K. S. T.; PRUCCOLI, L.; et al. A novel curcumin-donepezil hybrid as a potential multi-target drug. Neurodegenerative Diseases, v. 17, 2017.
2016
PEREIRA, R. M.; SILVA, G. A. F.; PIVATTO, M.; et al. Antiproliferative activity of alkaloids from Senna spectabilis on HepG2 cells. Toxicology in Vitro, v. 31, p. 86–92, 2016.
CASTRO, A. T.; CASTRO, A. P.; SILVA, M. S.; et al. Schistosomicidal effect of Senna spectabilis alkaloids. Bioorganic & Medicinal Chemistry Letters, 2016.
GONTIJO, V. S.; DOS SANTOS, M. H.; VIEGAS JR., C. Natural biflavonoids from plants: chemical and biological aspects. Mini-Reviews in Medicinal Chemistry, v. 16, 2016.
2015
DIAS, K. S. T.; PAULA, C. T.; RIQUIEL, M. M.; et al. Multi-target directed ligands for Alzheimer’s disease. Revista Virtual de Química, v. 7, p. 609–648, 2015.
GONTIJO, V. S.; JANUARIO, J. P.; JUDICE, W. A. S.; et al. Morelloflavone derivatives as protease inhibitors. Journal of Medicinal Plant Research, v. 9, p. 426–434, 2015.
FERNANDES, I. A.; ALMEIDA, L.; FERREIRA, P. E.; et al. Piperidine-benzodioxole derivatives as leishmanicidal candidates. Bioorganic & Medicinal Chemistry Letters, v. 25, p. 3346–3349, 2015.
SILVA, J. I.; NICASTRO, P. C.; OLIVEIRA, P. C. M.; et al. Comparative evaluation of acetylcholinesterase inhibition methods. Revista Virtual de Química, v. 7, p. 2334–2346, 2015.
DE ALMEIDA, L.; ALVES, K. F.; MACIEL-REZENDE, C. M.; et al. Benzophenone derivatives as cysteine protease inhibitors. Biomedicine & Pharmacotherapy, v. 75, p. 93–99, 2015.
Artigos Publicados
- 2026
Volonte, C.; Hu, G.; Shaw, C.; Viegas Jr., C.; et al. Neuroprotection Beyond Neurons: Integrated Biomarker-Based and Astroglia- or Microglia-Targeted Approaches to Combat Neurodegenerative Diseases. Exploration of Neuroprotective Therapy, v. 6, p. 1004136, 2026.
Invencio, C. G. G.; Lontra, A. C. P.; Paiva, J. P. B.; et al. Pharmacological characterization of the anti-nociceptive and anti-inflammatory effects of new CBD-based terpenyl-N-acyl-aryl-hydrazone analogues. Biomedicine & Pharmacotherapy, v. 194, p. 118925, 2026.
- 2025
Ureña, M. J. E.; Katchborian-Neto, A.; et al. Simarouba berteroana Krug & Urb. extracts and fractions possess anthelmintic activity against multidrug-resistant Haemonchus contortus. Veterinary Sciences, v. 12, p. 90–117, 2025.
Souza, M. L.; Paiva, J. P. B.; et al. Design, synthesis, and evaluation of antinociceptive properties of novel CBD-based terpene-cinnamoyl-acyl-hydrazone analogues. Pharmaceuticals, v. 18, p. 755, 2025.
Victor, M. M.; Ramos, G. S.; et al. Design, synthesis, and in vitro evaluation of the leishmanicidal activity of new aromatic symmetrical 1,4-disubstituted 1,2,3-bistriazoles. ACS Omega, 2025.
Franco, G. R. R.; Silva, I. M. F.; et al. New cannabidiol structure-related terpene N-acyl-hydrazones with potent antinociceptive and anti-inflammatory activity. Future Medicinal Chemistry, 2025.
Fonseca, R.; Louzano, Y. S.; et al. Curcumin-like compound inhibits proliferation of adenocarcinoma cells by inducing cell cycle arrest and senescence. Pharmaceuticals, v. 18, p. 914, 2025.
Ribeiro, L. V.; Massuda, L. E.; Gontijo, V. S.; Viegas Jr., C. Monoamine oxidase inhibitors in drug discovery against Parkinson’s disease: an update. Pharmaceuticals, v. 18, p. 1526–1605, 2025.
Franco, G. R. R.; Gontijo, V. S.; et al. Novel multifunctional cannabidiol-based analogues with in silico, in vitro, and in vivo anti-SARS-CoV-2 effect. Pharmaceuticals, v. 18, p. 1565, 2025.
Reis, V. E. N.; Franco, G. R. R.; et al. Evaluation of novel selective MAO-B inhibitors using immobilized enzymes on magnetic beads. Journal of Pharmaceutical and Biomedical Analysis, v. 268, p. 117200, 2025.
Baptistella, M. M.; Siqueira, A. P.; et al. Resveratrol-curcumin hybrid selectively induces chromosomal abnormalities and apoptosis in colon adenocarcinoma cells. Antioxidants, v. 14, p. 1367, 2025.
- 2024
Souza, A. A.; Viegas, F. P. D.; et al. Antinociceptive effect of Dillenia indica mediated by opioid and cannabinoid systems. Chemistry & Biodiversity, v. 21, p. 1–14, 2024.
Duarte Filho, L. A. M. S.; Leal, C. E. Y.; et al. Identification of peptide inhibitors of coronavirus 3CL protease from Fucus ceranoides. Marine Drugs, v. 22, p. 244, 2024.
Silva, I. M. F.; Franco, G. R. R.; Gontijo, V. S.; Viegas Jr., C. Protein kinases as therapeutic targets for Alzheimer’s disease: a brief review. Exploration of Neuroprotective Therapy, v. 4, p. 411–441, 2024.
Souza, M.; Franco, G. R. R.; et al. Analogues and derivatives of cannabidiol: pharmacological insights and recent efforts. Journal of the Brazilian Chemical Society, v. 35, 2024.
Freitas Silva, M.; Ortiz, C. J. C.; et al. Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids for Parkinson’s disease. Bioorganic Chemistry, v. 150, p. 107587, 2024.
- 2023
Ernesto, J. T.; Damasio, C. M.; et al. The role of the microbiota–gut–brain axis in neurodegenerative diseases. Exploration of Neuroprotective Therapy, v. 3, p. 71–89, 2023.
Pressete, C. G.; Viegas, F. P. D.; et al. Piperine–chlorogenic acid hybrid inhibits melanoma cell proliferation. Pharmaceuticals, v. 16, p. 145, 2023.
Baptistella, M. M.; Assunção, R. R. S.; et al. Synthetic resveratrol–curcumin hybrid exhibits chemopreventive effects. Journal of Pharmacy and Pharmacology, v. 76, p. 479–488, 2023.
Miguel de Oliveira, C.; Horvath, R.; et al. PQM-75: an N-benzyl-piperidine acyl-hydrazone derivative with antitumoral activity. Revista Virtual de Química, v. 15, p. 464–471, 2023.
Espino Ureña, M. J.; Katchborian-Neto, A.; et al. Chemical composition and anthelmintic activity of Lippia dominguensis essential oil. Chemistry & Biodiversity, v. 20, 2023.
- 2022
VAZ, S. M.; et al. Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s disease Bioorganic & Medicinal Chemistry, v. 71, p. 116952, 2022.
VIEGAS, F. P. D.; et al. Curcumin, resveratrol and cannabidiol as natural prototypes in neuroprotective drug design. Current Neuropharmacology, v. 20, p. 1297–1328, 2022.
CRISTANCHO ORTIZ, C. J.; et al. Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation. RSC Medicinal Chemistry, v. 13, p. 568–584, 2022.
2021
ETIENNE, R.; VIEGAS JR., C. Aspectos fisiopatológicos da inflamação e o planejamento de fármacos. Revista Virtual de Química, v. 13, p. 167–191, 2021.
DE SOUZA, A. A.; et al. Semysinthetic biflavonoid Morelloflavone-7,4′,7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin. Biochimica et Biophysica Acta, v. 1865, 2021.
2020
GONTIJO, V. S.; et al. Molecular hybridization as a tool in multi-target drug design for neurodegenerative diseases. Current Neuropharmacology, v. 18, p. 348–407, 2020.
SILVA, M. F.; et al. Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease.
Molecules, v. 25, 2020.
MAKHOBA, X. H.; et al. Potential Impact of multi-target drug approaches in complex diseases. Drug Design, Development and Therapy, v. 14, 2020.
PIROLLA, N. F. F.; et al. Alzheimer’s Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches. Current Drug Targets, v. 22, 2020.
ORTIZ, C. J. C.; et al. Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases. Neurochemical Research, v. 45, 2020.
VIEGAS, C.; FRAGA, C. A. M.; et al. Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases? Frontiers in Pharmacology, v. 11, 2020.
FRANCO, G. R. R.; VIEGAS, C. Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases. Current Neuropharmacology, v. 18, 2020.
2019
MORRONI, F.; SITA, G.; GRAZIOSI, A.; et al. PQM130, a novel feruloyl-donepezil hybrid compound, effectively ameliorates the cognitive impairments and pathology in a mouse model of Alzheimer’s disease. Frontiers in Pharmacology, v. 10, 2019.
CÉSAR DA SILVA, R.; VEIGA, F.; VILELA, F. C.; et al. Design, synthesis and pharmacological evaluation of novel anti-inflammatory and analgesic O-benzyloxime compounds derived from natural eugenol. Letters in Drug Design & Discovery, v. 16, p. 1157–1166, 2019.
BELLOZI, P. M. Q.; CAMPOS, A. C.; VIEGAS, F. P. D.; et al. New multifunctional AChE inhibitor drug prototypes protect against Aβ-induced memory deficit. Neurological Sciences, v. 2, p. 451–455, 2019.
2018
SILVA, M. F.; DIAS, K. S. T.; GONTIJO, V. S.; et al. Multi-target directed drugs as a modern approach for drug design towards Alzheimer’s disease: an update. Current Medicinal Chemistry, v. 25, p. 3491–3525, 2018.
SANTOS, N. M.; PEREIRA, N. C.; ALBUQUERQUE, A. P. S.; et al. 3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain mediated by opioid system. Biomedicine & Pharmacotherapy, v. 99, p. 492–498, 2018.
VIEGAS, F. P. D.; SILVA, M. F.; ROCHA, M. D.; et al. Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids. European Journal of Medicinal Chemistry, v. 147, p. 48–65, 2018.
DE FREITAS SILVA, M.; COELHO, L. F.; GUIRELLI, I. M.; et al. Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells Toxicology in Vitro, v. 50, p. 75–85, 2018.
FREITAS, T. R.; DANUELLO, A.; VIEGAS JR., C.; et al. Mass spectrometry for characterization of homologous piperidine alkaloids as acetylcholinesterase inhibitors. Rapid Communications in Mass Spectrometry, v. 33, p. 1303–1310, 2018.
DE FREITAS SILVA, M.; PRUCCOLI, L.; MORRONI, F.; et al. The Keap1/Nrf2-ARE pathway as a pharmacological target for chalcones. Molecules, v. 23, 2018.
SILVA, N. C.; CARVALHO, R. R.; CUSINATO, M.; et al. Promising synergistic activity of fluconazole with bioactive Guttiferone-A and derivatives against non-albicans Candida species Journal de Mycologie Médicale, 2018.
LACERDA, R. B. M.; FREITAS, T. R.; MARTINS, M. M.; et al. Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis Bioorganic & Medicinal Chemistry, v. 26, p. 5816–5823, 2018.
VICTOR, M. M.; FARIAS, R. R.; DA SILVA, D. L.; et al. Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions Medicinal Chemistry, v. 14, p. 400–408, 2018.
2017
COLOMBO, F. A.; REIS, R. A.; NUNES, J. B.; et al. In Vivo Evaluation of Leishmanicidal Activity of Benzophenone Derivatives by qPCR Medicinal Chemistry: Current Research, v. 7, p. 890–893, 2017.
SILVA, G. A. F.; ORTEGA, M. M.; BARIONIS, M. A.; et al. A novel ruthenium complex inhibits ERK activation in A549 cells. Toxicology in Vitro, v. 44, p. 382–391, 2017.
FRANCO, G. R. R.; VIEGAS JR., C. The contribution of cannabidiol and synthetic analogues in neuropsychiatric drug design. Revista Virtual de Química, v. 9, p. 1773–1798, 2017.
FREITAS, P.; CASTILHO, T. E.; ALMEIDA, L.; et al. In silico study of benzophenone derivatives against Trypanosoma cruzi and Leishmania. Journal of the Brazilian Chemical Society, 2017.
DIAS, K. S. T.; DE PAULA, C. T.; DOS SANTOS, T.; et al. Design, synthesis and evaluation of novel feruloyl-donepezil hybrids. European Journal of Medicinal Chemistry, v. 130, p. 440–457, 2017.
TAROZZI, A.; DIAS, K. S. T.; PRUCCOLI, L.; et al. A novel curcumin-donepezil hybrid as a potential multi-target drug. Neurodegenerative Diseases, v. 17, 2017.
2016
PEREIRA, R. M.; SILVA, G. A. F.; PIVATTO, M.; et al. Antiproliferative activity of alkaloids from Senna spectabilis on HepG2 cells. Toxicology in Vitro, v. 31, p. 86–92, 2016.
CASTRO, A. T.; CASTRO, A. P.; SILVA, M. S.; et al. Schistosomicidal effect of Senna spectabilis alkaloids. Bioorganic & Medicinal Chemistry Letters, 2016.
GONTIJO, V. S.; DOS SANTOS, M. H.; VIEGAS JR., C. Natural biflavonoids from plants: chemical and biological aspects. Mini-Reviews in Medicinal Chemistry, v. 16, 2016.
2015
DIAS, K. S. T.; PAULA, C. T.; RIQUIEL, M. M.; et al. Multi-target directed ligands for Alzheimer’s disease. Revista Virtual de Química, v. 7, p. 609–648, 2015.
GONTIJO, V. S.; JANUARIO, J. P.; JUDICE, W. A. S.; et al. Morelloflavone derivatives as protease inhibitors. Journal of Medicinal Plant Research, v. 9, p. 426–434, 2015.
FERNANDES, I. A.; ALMEIDA, L.; FERREIRA, P. E.; et al. Piperidine-benzodioxole derivatives as leishmanicidal candidates. Bioorganic & Medicinal Chemistry Letters, v. 25, p. 3346–3349, 2015.
SILVA, J. I.; NICASTRO, P. C.; OLIVEIRA, P. C. M.; et al. Comparative evaluation of acetylcholinesterase inhibition methods. Revista Virtual de Química, v. 7, p. 2334–2346, 2015.
DE ALMEIDA, L.; ALVES, K. F.; MACIEL-REZENDE, C. M.; et al. Benzophenone derivatives as cysteine protease inhibitors. Biomedicine & Pharmacotherapy, v. 75, p. 93–99, 2015.
