| Authors |
Title (click to access the publication) |
Journal |
Year |
| Etienne, R. et al. |
Aspectos fisiopatológicos da inflamação e o planejamento de fármacos: uma visão geral atualizada. |
Revista Virtual De Química |
2021 |
| Gontijo, Vanessa Silva, et al. |
Molecular Hybridization as a Tool in the Design of Multi-Target Directed Drug Candidates for Neurodegenerative Diseases. |
Current Neuropharmacology |
2020 |
| Silva, M. F. et al. |
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease. |
Molecules |
2020 |
| Makhoba, X. H. et al. |
Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases |
Drug Design Development And Therapy |
2020 |
| Pirolla, N. F. F. et al. |
Alzheimer’s Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development, and Promising Results Obtained from Multi-target Approaches |
Current Drug Targets |
2020 |
| Viegas Jr, et al. |
EDITORIAL Oxidative Stress: How has it been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases? |
Frontiers In Pharmacology |
2020 |
| Ortiz, C. J. C. et al. |
Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases. |
Neurochemical Research |
2020 |
| dos Reis Franco, et al. |
Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases. |
Current Neuropharmacology |
2020 |
| Morroni, F. et al. |
PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease? |
Frontiers In Pharmacology |
2019 |
| Bellozi, Paula M. Q. et al. |
New multifunctional ache inhibitor drug prototypes protect against Aβ-induced memory deficit. |
Neurological Sciences |
2019 |
| Silva, M. F. et al. |
Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimers Disease: An Update. |
Current Medicinal Chemistry |
2018 |
| Santos, N. M. et al. |
3-Hydroxy-piperidinyl- N -benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system. |
Biomedicine & Pharmacotherapy |
2018 |
| Viegas, F. P. D. et al. |
Design, synthesis and pharmacological evaluation of N -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates. |
European Journal Of Medicinal Chemistry |
2018 |
| de Freitas Silva, Matheus, et al. |
Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells. |
Toxicology In vitro |
2018 |
| de Freitas Silva, Matheus, et al. |
He Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones. |
Molecules |
2018 |
| Colombo, F. A. et al. |
In vivo Evaluation of Leishmanicidal Activity of Benzophenone Derivatives by qPCR. |
Medicinal Chemistry: Current Research |
2017 |
| Franco, G. R. R. & Viegas, Jr |
The Contribution of Studies with Canabidiol and Synthetic Analogues in the Design of New Drug Candidates for Neuropsychiatric Disorders and Neurodegenerative Diseases. |
Revista Virtual De Química |
2017 |
| Dias, Kris Simone T. et al. |
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer’s disease. |
European Journal Of Medicinal Chemistry |
2017 |
| Pereira, R. M. et al. |
Alkaloids derived from flowers of Senna spectabilis, (−)-cassine and (−)-spectaline, have antiproliferative activity on HEPG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression. |
Toxicology In vitro |
2016 |
| Castro, A. T. et al. |
In vitro Evaluation of the Schistosomicidal Effect of the Extracts, Fractions and major 3-Hydroxy-2,6-Dialkyl-Substituted Piperidine Alkaloids from the Flowers of Senna spectabilis (Fabaceae). |
Bioorganic & Medicinal Chemistry Letters (Print) |
2016 |
| Gontijo, V. S. et al. |
Biological and Chemical Aspects of Natural Biflavonoids from Plants: a Brief Review. |
Mini-Reviews In Medicinal Chemistry |
2016 |
| Dias, K. S. T. et al. |
Recent Applications of the Multi¬Target Directed Ligands Approach for the Treatment of Alzheimer’s Disease. |
Revista Virtual De Química |
2015 |
| Fernandes, I. A. et al. |
Synthesis and biological evaluation of novel piperidine-benzodioxole derivatives designed as potential leishmanicidal drug candidates. |
Bioorganic & Medicinal Chemistry Letters (Print) |
2015 |
| Dias, K. S. T & Viegas, Jr. |
Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer-s Disease. |
Current Neuropharmacology |
2014 |
| Simões, M. C. R. et al. |
Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimer’s Disease |
Mini-Reviews in Medical Chemistry |
2011 |
| Dias, K. S. T. et al. |
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives. |
Bioorganic & Medicinal Chemistry (Print) |
2012 |
| Gontijo, V. S. et al. |
Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives. |
European Journal Of Medicinal Chemistry |
2012 |
| Rocha, M. D. et al. |
The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease. |
Cns & Neurological Disorders. Drug Targets |
2011 |
| Viegas, Cláudio Jr. et al |
CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline. |
European Journal Of Pharmacology |
2008 |
| Viegas, Cláudio Jr. et al. |
Diastereosseletividade na redução de enonas bicíclicas com hidretos volumosos. |
Química Nova (Impresso) |
2008 |
| Viegas, Cláudio Jr. et al. |
Molecular Hybridization: A useful tool in the design of new drug prototypes. |
Current Medicinal Chemistry |
2007 |
| Viegas, Cláudio Jr. et al. |
Os produtos naturais e a química medicinal moderna. |
Química Nova (Impresso) |
2006 |
| Viegas, Cláudio Jr. et al. |
New anti-alzheimer drugs from biodiversity: the role of the natural acetylcholinesterase inhibitors. |
Mini-Reviews In Medicinal Chemistry |
2005 |
| Viegas, Cláudio Jr. et al. |
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids. |
Bioorganic & Medicinal Chemistry |
2005 |
| Viegas, Cláudio Jr. et al. |
Produtos Naturais como Candidatos a Fármacos Úteis no Tratamento do Mal de Alzheimer. |
Química Nova (Impresso) |
2004 |
| Viegas, Cláudio Jr. et al. |
Further Bioactive Piperidine Alkaloids from the Flowers and Green Fruits of Cassia spectabilis. |
Journal Of Natural Products (Print) |
2004 |
| Moreira, Magna Suzana Alexandre et al. |
Analgesic Profile of (-)-espectaline: A Piperidine Alkaloid from Cassia leptophylla (Leguminosae). |
Planta Medica |
2003 |
