Linha de pesquisa

Avaliação da atividade biológica de produtos naturais e sintéticos sobre células tumorais

Discentes

Colaboradores Externos

Publicações Recentes

• 1. DIAS, JÚLIA S. M. ; FERREIRA-SILVA, GUILHERME A. ; VIANA, ROMMEL B. ; DE ARAUJO NETO, JOÃO H. ; ELLENA, JAVIER ; CORRÊA, RODRIGO S. ; BARBOSA, MARÍLIA I. F. ; Ionta, Marisa ; DORIGUETTO, ANTÔNIO C. . Ruthenium(II) Complex with 1-Hydroxy-9,10-Anthraquinone Inhibits Cell Cycle Progression at G0/G1 and Induces Apoptosis in Melanoma Cells. PHARMACEUTICALS, v. 18, p. 63, 2025.
• 2. OLIVEIRA-SILVA, JOÃO MARCOS ; OLIVEIRA, LEILANE SALES ; CHIMINAZO, CAROLINA BERRAUT ; FONSECA, RAFAEL ; DE SOUZA, CARLOS VINICIUS EXPEDITO ; AISSA, ALEXANDRE FERRO ; DE ALMEIDA LIMA, GRAZIELA DOMINGUES ; Ionta, Marisa ; CASTRO-GAMERO, ANGEL MAURICIO . WT161, a selective HDAC6 inhibitor, decreases growth, enhances chemosensitivity, promotes apoptosis, and suppresses motility of melanoma cells. CANCER CHEMOTHERAPY AND PHARMACOLOGY, v. 95, p. 1, 2025.
• 3. NAVES, VALÉRIA DE MOURA LEITE ; BRUZADELLI, RAFAELA FRANCO DIAS ; Ionta, Marisa ; GREMIÃO, MARIA PALMIRA DAFLON ; PEDREIRO, LILIANE NEVES ; PEREIRA, GISLAINE RIBEIRO ; CARVALHO, FLÁVIA CHIVA . Uptake and Inhibition of P-Glycoprotein-Mediated Efflux Evaluation of Encapsulated Methotrexate Chitosan and Hypromellose Phthalate Nanoparticles for Potential Glioblastoma Treatment. PHARMACEUTICS, v. 17, p. 239, 2025.
• 4. VICTOR, MAURÍCIO MORAES ; RAMOS, GABRIEL DOS SANTOS ; ANDRADE, BRUNO SILVA ; SEPIN, PATRÍCIA FERREIRA ESPURI ; FERREIRA-SILVA, GUILHERME ÁLVARO ; Ionta, Marisa ; MORAIS, AMANDA ALMEIDA ; GONTIJO, VANESSA SILVA ; VIEGAS, CLAUDIO ; MARQUES, MARCOS JOSÉ . Design, Synthesis, and In Vitro Evaluation of the Leishmanicidal Activity of New Aromatic Symmetrical 1,4-Disubstituted 1,2,3-Bistriazoles. ACS Omega, v. 1, p. 1, 2025.
• 5. ANDRADE, AMANDA APARECIDA RIBEIRO ; PAULI, FERNANDA ; PRESSETE, CAROLINA GIROTTO ; ZAVAN, BRUNO ; HANEMANN, JOÃO ADOLFO COSTA ; MIYAZAWA, MARTA ; FONSECA, RAFAEL ; CAIXETA, ESTER SIQUEIRA ; NACIF, JULIA LOUISE MOREIRA ; AISSA, ALEXANDRE FERRO ; BARREIRO, ELIEZER J. ; Ionta, Marisa . Antiproliferative Activity of N-Acylhydrazone Derivative on Hepatocellular Carcinoma Cells Involves Transcriptional Regulation of Genes Required for G2/M Transition. Biomedicines, v. 12, p. 892, 2024.
• 6. TRISTAO SANTINI, AMANDA ; OTACÍLIO PINTO, RAYRA ANNARA ; GOLDONI LAZARINI, JOSY ; VIEIRA DE MORAIS, DANIEL ; ALVES DE PILOTO FERNANDES, ANNA MARIA ; FRANCHIN, MARCELO ; LUNARDELLI NEGREIROS DE CARVALHO, PATRICIA ; GIROTTO PRESSETE, CAROLINA ; ROSALEN, PEDRO LUIZ ; MATIAS DE ALENCAR, SEVERINO ; DE OLIVEIRA CARVALHO, PATRICIA ; Ionta, Marisa ; IKEGAKI, MASAHARU . BIOACTIVES OF Melipona rufiventris PROPOLIS: EXPLORING ITS ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITIES. CHEMISTRY & BIODIVERSITY, v. 17, p. 1, 2024.
• 7. GARCIA, DANIELA A. ; COSTA, LARA P. D.M. ; ROSA, WELTON ; LADVOCAT, ANA CLÁUDIA ; DIAS, DANIELLE F. ; SOARES, MARISI G. ; Ionta, Marisa ; CHAGAS DE PAULA, DANIELA APARECIDA . Antiproliferative potential of essential oil from the leaves of Croton floribundus (Euphorbiaceae) against human metastatic melanoma cell lines. CHEMISTRY & BIODIVERSITY, v. 1, p. 1, 2024.
• 8. GARCIA, DANIELA A. ; PRESSETE, CAROLINA G. ; MIRANDA, RAFAEL ; SALEM, PAULA P.O. ; NICÁCIO, KAREN J. ; COSTA, LARA P.D.M. ; MURGU, MICHAEL ; LAGO, JOÃO H.G. ; DIAS, DANIELLE F. ; SOARES, MARISI G. ; Ionta, Marisa ; CHAGAS-PAULA, DANIELA A. . Biological and metabolomics-guided isolation of tetrahydrofurofuran lignan from Croton spp. with antiproliferative activity against human melanoma cell line. FITOTERAPIA, v. 1, p. 106070, 2024.
• 9. FERREIRA-SILVA, GUILHERME ÁLVARO ; RODRIGUES, DANIEL ALENCAR ; PRESSETE, CAROLINA GIROTTO ; CAIXETA, ESTER SIQUEIRA ; GAMERO, ANGEL MAURICIO CASTRO ; MIYAZAWA, MARTA ; HANEMANN, JOÃO ADOLFO COSTA ; FRAGA, CARLOS ALBERTO MANSSOUR ; AISSA, ALEXANDRE FERRO ; Ionta, Marisa . Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells. TOXICOLOGY IN VITRO, v. 99, p. 105884-105884, 2024.
• 10. BRUSTOLIN BRAGA, CAROLYNE ; MILAN, JULIO CESAR ; ANDRADE MEIRELLES, MATHEUS ; ZAVAN, BRUNO ; FERREIRA-SILVA, GUILHERME ÁLVARO ; CAIXETA, ESTER SIQUEIRA ; Ionta, Marisa ; PILLI, RONALDO A. . Furoxan-piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation. Rsc Medicinal Chemistry, v. 1, p. 1, 2024.