Profa. Dra. Marisa Ionta

                                                            Grupo de Pesquisa

Bases moleculares envolvidas na atividade antitumoral de compostos naturais e sintéticos

                                                     

 

Linha de pesquisa

Avaliação da atividade biológica de produtos naturais e sintéticos sobre células tumorais

 

Discentes

Bruno Zavan (Pós-doutorado)

Guilherme Álvaro Ferreira da Silva (Doutorado)

Amanda Alvim Negreti (Doutorado)

Carolina Girotto Presseti (Doutorado)

Melissa Lúcia Melo (Mestrado)

Amanda Aparecida Ribeiro Andrade (Mestrado)

Rafael Fonseca Miranda (Iniciação científica)

 

Colaboradores Externos

  • INCT INOFAR/RJ
  • Prof. Dr. Marcelo Henrique dos Santos (UFV)
  • Profa. Dra. Maria das Graças Cardoso (UFLA)
  • Profa. Dra. Patrícia Sartorelli (UNIFESP)

 

Artigos Publicados

1. FOLQUITTO, LAÍS ; DE SOUZA, THIAGO ; JANUARIO, JAQUELINE ; NASCIMENTO, ISADORA ; BRANDÃO, BRENDA ; MOREIRA, MARIA ; HORVATH, RENATO ; SANTOS, MARCELO ; COELHO, LUIZ ; VELOSO, MARCIA ; SOARES, MARISI ; CARVALHO, DIOGO ; Ionta, Marisa ; CHAGAS-PAULA, DANIELA ; DIAS, DANIELLE . Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 00, p. 1-13, 2022.
2. DIAS, MARIA ; DE SOUSA, BIANCA ; Ionta, Marisa ; TEIXEIRA, RÓBSON ; GOULART, THIAGO ; FERREIRA-SILVA, GUILHERME ; PILAU, EDUARDO ; DOS SANTOS, MARCELO . Synthesis of 1,2,3-Triazole Benzophenone Derivatives and Evaluation of in vitro Sun Protection, Antioxidant Properties, and Antiproliferative Activity on HT-144 Melanoma Cells. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY (ONLINE), v. 00, p. 1, 2021.
3. SANTOS, AUGUSTO L. ; Ionta, Marisa ; HORVATH, RENATO ; SOARES, MARISI G. ; MEDEIROS, LÍVIA S. DE ; UEMI, MIRIAM ; KAWAFUNE, EUNIZINIS S. ; TANGERINA, MARCELO M.P. ; FERREIRA, MARCELO J.P. ; SARTORELLI, PATRICIA . Molecular network for accessing polyketide derivatives from Phomopsis sp., an endophytic fungus of Casearia arborea (Salicaceae). Phytochemistry Letters, v. 42, p. 1-7, 2021.
4. GRIGOLO, THIAGO A. ; BRAGA, CAROLYNE B. ; ORNELAS, CATIA ; RUSSOWSKY, DENNIS ; FERREIRA-SILVA, GUILHERME A. ; Ionta, Marisa ; PILLI, RONALDO A. . Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents. BIOORGANIC CHEMISTRY, v. 116, p. 105292, 2021.
5. ÁLVARO FERREIRA DA SILVA, GUILHERME ; CARDOSO, MARIA DAS GRAÇAS ; IONTA, M. . Genotoxic, cytotoxic and fungicidal activity of the essential oil extracted from the leaves and fruits of the pink pepper (Schinus terebinthifolius Raddi). AUSTRALIAN JOURNAL OF CROP SCIENCE (ONLINE), v. 15, p. 997-1004, 2021.
6. SCAFF MOREIRA DIAS, JÚLIA ; VIEIRA REIS SILVA, HENRIQUE ; CESAR CANDIDO, CAIO ; ÁLVARO FERREIRA DA SILVA, GUILHERME ; Ionta, Marisa ; ALMEIDA, FERNANDO ; BEZERRA VIANA, ROMMEL ; IMACULADA FRAZÃO BARBOSA, MARÍLIA ; CARLOS DORIGUETTO, ANTÔNIO . Novel ruthenium(II) complexes with cimetidine: DFT calculations and in vitro cytotoxic activities against glioblastoma cell lines. INORGANICA CHIMICA ACTA, v. 506, p. 119501, 2020.
7. MAGALHÃES, MAÍSA LAMOUNIER ; Ionta, Marisa ; FERREIRA, GUILHERME ÁLVARO ; CAMPIDELLI, MARINA LEOPOLDINA LAMOUNIER ; NELSON, DAVID LEE ; FERREIRA, VANUZIA RODRIGUES FERNANDES ; REZENDE, DANUBIA APARECIDA DE CARVALHO SELVA ; CARDOSO, MARIA DAS GRAÇAS . Biological activities of the essential oil from the Moro orange peel ( Citrus sinensis (L.) Osbeck). FLAVOUR AND FRAGRANCE JOURNAL (ONLINE), v. 35, p. 294-301, 2020.
8. OSORIO, LISETH ; Ionta, Marisa ; DEMUNER, ANTONIO ; DE SOUSA, BIANCA ; FERRAZ, GUILHERME ; VAREJÃO, EDUARDO ; FERREIRA-SILVA, GUILHERME ; PILAU, EDUARDO ; SILVA, EVANDRO ; DOS SANTOS, MARCELO . Synthesis of 1,2,3-Triazole Derivatives of Hydnocarpic Acid Isolated from Carpotroche brasiliensis Seed Oil and Evaluation of Antiproliferative Activity. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 00, p. 1, 2020.
9. DA SILVA LAMARTINE HANEMANN, SIMONE ; FERREIRA-SILVA, GUILHERME ÁLVARO ; DE OLIVEIRA HORVATH, RENATO ; SONCINI, ROSELI ; CAIXETA, ESTER SIQUEIRA ; SALES, BIANCA ROCHA ; DE OLIVEIRA NIERO, EVANDRO LUÍS ; MACHADO-SANTELLI, GLAUCIA MARIA ; DOS SANTOS, MARCELO HENRIQUE ; DE OLIVEIRA, JAQUELINE CARVALHO ; MIYAZAWA, MARTA ; Ionta, Marisa . A tetraprenylated benzophenone 7-epiclusianone induces cell cycle arrest at G1/S transition by modulating critical regulators of cell cycle in breast cancer cell lines. TOXICOLOGY IN VITRO, v. 68, p. 104927, 2020.
10. PAULI, FERNANDA P. ; MARTINS, JULIANA R. ; PASCHOALIN, THAYSA ; Ionta, Marisa ; BARBOSA, MARIA LETICIA C. ; BARREIRO, ELIEZER J. . Novel VEGFR-2 inhibitors with an -acylhydrazone scaffold. ARCHIV DER PHARMAZIE, v. 353, p. 1, 2020.
11. DE CASTRO, MAYARA SANTOS ; MIYAZAWA, MARTA ; NOGUEIRA, ESTER SIQUEIRA CAIXETA ; CHAVASCO, JORGE KLEBER ; BRANCAGLION, GUSTAVO ANDRADE ; CERDEIRA, CLÁUDIO DANIEL ; NOGUEIRA, DENISMAR ALVES ; Ionta, Marisa ; HANEMANN, JOÃO ADOLFO COSTA ; BRIGAGÃO, MAÍSA RIBEIRO PEREIRA LIMA ; SPERANDIO, FELIPE FORNIAS . Photobiomodulation enhances the Th1 immune response of human monocytes. LASERS IN MEDICAL SCIENCE, v. 00, p. 1-14, 2020.
12. ROSA, ISAEL APARECIDO ; DE’OLIVEIRA’SILVA’GIACOPPO, JULIANA ; DA’CUNHA, ELAINE F. F. ; FERNANDES, ÍTALO ANTÔNIO ; DE’OLIVEIRA’HORVATH, RENATO ; Ionta, Marisa ; DOS’SANTOS, MARCELO HENRIQUE ; RAMALHO, TEODORICO C. . Structure-Based Virtual Screening and Synthesis of Mn 2+ Complexes of Benzothiazole Derivatives for Designing New MRI Probes. ChemistrySelect, v. 4, p. 3118-3122, 2019.
13. AZEVEDO-BARBOSA, HELLOANA ; FERREIRA-SILVA, GUILHERME ÁLVARO ; SILVA, CAROLINA FARIA ; DE SOUZA, THIAGO BELARMINO ; DIAS, DANIELLE FERREIRA ; DE PAULA, ANA CLAUDIA CHAGAS ; Ionta, Marisa ; CARVALHO, DIOGO TEIXEIRA . Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line. TOXICOLOGY IN VITRO, v. 59, p. 150-160, 2019.
14. NAVES, V.M.L. ; DOS SANTOS, M.H. ; RIBEIRO, I.S. ; DA SILVA, C.A. ; SILVA, N.C. ; DA SILVA, M.A. ; DA SILVA, G.A. ; DIAS, A.L.T. ; IONTA, M. ; DIAS, D.F. . Antimicrobial and antioxidant activity of Garcinia brasiliensis extracts. SOUTH AFRICAN JOURNAL OF BOTANY, v. 124, p. 244-250, 2019.
15. DIAS VIEGAS, FLÁVIA PEREIRA DE FREITAS SILVA, MATHEUS DIVINO DA ROCHA, MIGUEL CASTELLI, MAÍSA ROSA RIQUIEL, MARIANA MÁXIMO MACHADO, RAFAEL PEREIRA VAZ, SARAH MACEDO SIMÕES DE LIMA, LAÍS MEDEIROS MANCINI, KARLA CRISTINE MARQUES DE OLIVEIRA, PATRÍCIA CRUZ MORAIS, ÉLIDA PARREIRA GONTIJO, VANESSA SILVA DA SILVA, FERNANDA MOTTA R. D’ALINCOURT DA FONSECA PEÇANHA, DORA CASTRO, NEWTON GONÇALVES NEVES, GILDA A. GIUSTI-PAIVA, ALEXANDRE VILELA, FABIANA CARDOSO ORLANDI, LIDIANE CAMPS, IHOSVANY VELOSO, MÁRCIA PARANHO LEOMIL COELHO, LUIS FELIPE Ionta, Marisa FERREIRA-SILVA, GUILHERME ÁLVARO PEREIRA, RODRIGO MACHADO , et al. ; Design, synthesis and pharmacological evaluation of N -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 147, p. 48-65, 2018.
16. SILVA, HENRIQUE VIEIRA REIS ; DIAS, JÚLIA SCAFF MOREIRA ; FERREIRA-SILVA, GUILHERME ÁLVARO ; VEGAS, LEGNA COLINA ; Ionta, Marisa ; CORRÊA, CHARLANE CIMINI ; BATISTA, ALZIR AZEVEDO ; BARBOSA, MARÍLIA IMACULADA FRAZÃO ; DORIGUETTO, ANTÔNIO CARLOS . Phosphine/diimine ruthenium complexes with Cl − , CO, NO + , NO 2 − , NO 3 − and pyridine ligands: Pro-apoptotic activity on triple-negative breast cancer cells and DNA/HSA interactions. POLYHEDRON, v. 144, p. 55-65, 2018.
17. DE FREITAS SILVA, MATHEUS ; COELHO, LETÍCIA FERREIRA ; GUIRELLI, ISADORA MITESTAINER ; PEREIRA, RODRIGO MACHADO ; DA SILVA, GUILHERME ÁLVARO FERREIRA ; GRARAVELLI, GRACIANA Y. ; DE OLIVEIRA HORVATH, RENATO ; NOGUEIRA, ESTER SIQUEIRA CAIXETA ; Ionta, Marisa ; VIEGAS, CLAUDIO . Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive mcf-7 breast cancer cells. TOXICOLOGY IN VITRO, v. 50, p. 75, 2018.
18. DIAS, JÚLIA SCAFF MOREIRA ; SILVA, HENRIQUE VIEIRA REIS ; DA SILVA, GUILHERME ÁLVARO FERREIRA ; Ionta, Marisa ; CORRÊA, CHARLANE CIMINI ; ALMEIDA, FERNANDO ; COLINA-VEGAS, LEGNA ; BARBOSA, MARÍLIA IMACULADA FRAZÃO ; DORIGUETTO, ANTÔNIO CARLOS . Pro-apoptotic activity of ruthenium 1-methylimidazole complex on non-small cell lung cancer. JOURNAL OF INORGANIC BIOCHEMISTRY, v. 183, p. 1-13, 2018.
19. CALDAS, LHAÍS ARAÚJO ; HORVATH, RENATO O. ; FERREIRA-SILVA, GUILHERME ÁLVARO ; FERREIRA, MARCELO J. P. ; Ionta, Marisa ; SARTORELLI, PATRICIA . Calein C, a Sesquiterpene Lactone Isolated From Calea Pinnatifida (Asteraceae), Inhibits Mitotic Progression and Induces Apoptosis in MCF-7 Cells. Frontiers in Pharmacology, v. 9, p. 1, 2018.
20. MASSONI, MURILO ; CLAVIJO, JUAN C. TENORIO ; COLINA-VEGAS, LEGNA ; VILLARREAL, WILMER ; DIAS, JULIA S.M. ; DA SILVA, GUILHERME A.F. ; Ionta, Marisa ; SOARES, MARISI ; ELLENA, JAVIER ; DORIGUETO, ANTÔNIO C. ; BARBOSA, MARÍLIA I.F. ; BATISTA, ALZIR A. . Propyl gallate metal complexes: Circular dichroism, BSA-binding, antioxidant and cytotoxic activity. POLYHEDRON, v. 129, p. 214-221, 2017.
21. FERREIRA-SILVA, GUILHERME A. ; ORTEGA, MARINA M. ; BANIONIS, MARCO A. ; GARAVELLI, GRACIANA Y. ; MARTINS, FELIPE T. ; DIAS, JULIA S.M. ; VIEGAS, CLÁUDIO ; DE OLIVEIRA, JAQUELINE C. ; DO NASCIMENTO, FABIO B. ; DORIGUETTO, ANTONIO C. ; BARBOSA, MARILIA I.F. ; Ionta, Marisa . [Ru(pipe)(dppb)(bipy)]PF 6 : A novel ruthenium complex that effectively inhibits ERK activation and cyclin D1 expression in A549 cells. TOXICOLOGY IN VITRO, v. 17, p. 30205, 2017.
22. PEREIRA, RODRIGO MACHADO ; FERREIRA-SILVA, GUILHERME ÁLVARO ; PIVATTO, MARCOS ; SANTOS, LUCIANA DE ÁVILA ; BOLZANI, VANDERLAN DA SILVA ; CHAGAS DE PAULA, DANIELA APARECIDA ; OLIVEIRA, JAQUELINE CARVALHO DE ; VIEGAS JÚNIOR, CLÁUDIO ; Ionta, Marisa . Alkaloids derived from flowers of Senna spectabilis, (−)-cassine and (−)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression. Toxicology in Vitro, v. 31, p. 86-92, 2016.
23. FERREIRA-SILVA, GUILHERME ÁLVARO ; LAGES, CARLA CAROLINA LOPES ; SARTORELLI, PATRICIA ; HASEGAWA, FLÁVIA RIE ; SOARES, MARISI GOMES ; Ionta, Marisa . Casearin D inhibits ERK phosphorylation and induces downregulation of cyclin D1 in HepG2 cells. Toxicology in Vitro, v. 38, p. 27-32, 2016.
24. SALES, LEILANE ; FERREIRA-SILVA, GUILHERME ÁLVARO ; GAMERO, A. M. C. ; IONTA, M. ; OLIVEIRA, JAQUELINE CARVALHO DE . YM155 induces apoptosis in p53-deficient T-acute lymphoblastic leukemia cells independent of survivin inhibition. ANTI-CANCER DRUGS, p. 1, 2016.
25. RODRIGUES, DANIEL A. ; FERREIRA-SILVA, GUILHERME À. ; FERREIRA, ANA C. S. ; FERNANDES, RENAN A. ; KWEE, JOLIE K. ; SANTANNA, CARLOS M. R. ; Ionta, Marisa ; FRAGA, CARLOS A. M. . Design, Synthesis, and Pharmacological Evaluation of Novel N -Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, v. 59, p. 655-670, 2016.
26. TEIXEIRA, VANESSA P. ; CERVILHA, DANIELA A. B. ; CABRAL, LAYLA D. M. ; OLIVEIRA, LUIZ M. ; INCERPI, ERIKA K. ; NOVAES, RÔMULO D. ; Ionta, Marisa ; SONCINI, ROSELI . Postnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol. Journal of Physiological Sciences, v. 66, p. 221-228, 2016.
27. Ionta, Marisa; FERREIRA-SILVA, GUILHERME ; NIERO, EVANDRO ; COSTA, ÉDERSON ; MARTENS, ADAM ; ROSA, WELTON ; SOARES, MARISI ; MACHADO-SANTELLI, GLÁUCIA ; LAGO, JOÃO ; SANTOS, MARCELO . 7-Epiclusianone, a Benzophenone Extracted from Garcinia brasiliensis (Clusiaceae), Induces Cell Cycle Arrest in G1/S Transition in A549 Cells. Molecules (Basel. Online), v. 20, p. 12804-12816, 2015.
28. DIONÍSIO, ANA PAULA ; CARVALHO-SILVA, LUCIANO BRUNO DE ; VIEIRA, NARA MENEZES ; GOES, TALITA DE SOUZA ; WURLITZER, NEDIO JAIR ; BORGES, MARIA DE FATIMA ; BRITO, EDY SOUSA DE ; Ionta, Marisa ; FIGUEIREDO, RAIMUNDO WILANE DE . Cashew-apple (Anacardium occidentale L.) and yacon (Smallanthus sonchifolius) functional beverage improve the diabetic state in rats. Food Research International, v. XXX, p. FRIN-05936, 2015.
29. DE OLIVEIRA, CHRISTIANE MARIA ; GRAÇAS CARDOSO, MARIA DAS ; Ionta, Marisa ; SOARES, MARISI GOMES ; ANDRADE SANTIAGO, JULIANA DE ; DA SILVA, GUILHERME ÁLVARO FERREIRA ; TEIXEIRA, MARIA LUISA ; SELVATI REZENDE, DANÚBIA APARECIDA DE CARVALHO ; DE SOUZA, RAFAELA VIEIRA ; SOARES, LUANA ISAC ; NELSON, DAVID LEE ; SOUSA CARVALHO, MARCOS SCHLEIDEN . Chemical Characterization and in Vitro Antitumor Activity of the Essential Oils from the Leaves and Flowers of Callistemon viminalis. American Journal of Plant Sciences, v. 06, p. 2664-2671, 2015.
30. SALES, LEILANE ; PEZUK, JULIA ALEJANDRA ; BORGES, KLEITON SILVA ; BRASSESCO, MARÍA SOL ; SCRIDELI, CARLOS ALBERTO ; TONE, LUIZ GONZAGA ; SANTOS, MARCELO HENRIQUE DOS ; Ionta, Marisa ; OLIVEIRA, JAQUELINE CARVALHO DE . Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma. BMC Complementary and Alternative Medicine (Online), v. 15, p. 1-8, 2015.
31. ZANIN, JOÃO L. B. ; MASSONI, MURILO ; SANTOS, MARCELO H. DOS ; FREITAS, GIOVANA C. DE ; NIERO, EVANDRO L. O. ; SCHEFER, RENATA R. ; LAGO, JOÃO H. G. ; Ionta, Marisa ; SOARES, MARISI G. . Caesalpinioflavone, a New Cytotoxic Biflavonoid Isolated from Caesalpinia pluviosa var. peltophoroides. Journal of the Brazilian Chemical Society (Impresso), v. 26, p. 804-809, 2015.
32. CARVALHO, B. A. ; DOMINGOS, O. S. ; Massoni, M ; dos Santos, MH ; IONTA, M. ; LAGO, J. H. G. ; Figueiredo, CR ; Matsuo, AL ; SOARES, M. G. . Essential Oil from Caesalpinia peltophoroides Flowers ? Chemical Composition and in vitroCytotoxic Evaluation. Natural Product Communications (Online), v. 8, p. 679-682, 2013.
33. IONTA, M.; ROSA, M.C. ; ALMEIDA, R.B. ; FREITAS, V.M. ; REZENDE-TEIXEIRA, P. ; MACHADO-SANTELLI, G.M. . Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation. Brazilian Journal of Medical and Biological Research (on line), v. 45, p. 721-729, 2012.
34. Rangel, Marisa ; Ionta, Marisa ; Pfister, Sandra ; Sant’Anna Ferreira, Raphael ; Machado-Santelli, Glaucia . Marine sponge depsipeptide increases gap junction length in HTC cells transfected with Cx43-GFP. Cell Biology International Reports, p. e00003, 2010.
35. IONTA, M.; Sant’ana Ferreira, Raphael A ; Pfister, Sandra C ; Machado-Santelli, Glaucia M . Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junction.. Cancer Cell International (Online), v. 9, p. 22, 2009.
36. Vaz-de-Lima, B.B. ; IONTA, M. ; MACHADO-SANTELLI, G. M. . Changes in cell morphology affect the quantification of intercellular communication. Micron (Oxford), v. 39, p. 631-634, 2008.

 

Capítulos de Livros Publicados

1. Machado-Santelli, Glaucia M ; IONTA, M. . Gap Junctions intercellular communication and connexin expression in normal liver cells and its change in hepatocarcinomas. Hepatocellular Carcinoma Book 1. : InTech, 2011, v. , p. -.