Publicações – Laboratório de Pesquisa em Química Farmacêutica

As publicações listadas adiante são alguns exemplos representativos de trabalhos desenvolvidos no LQFar ou que são provenientes de participação de seus membros, como colaboradores, em projetos de outros grupos.

Artigos

4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection.
A New 1,2-Benzisoxazolin-3-one Synthetized from Eugenol Shows Anti- Candida Spp. Activity, Specially Against Opportunistic Candida Glabrata.
Action of N-Succinyl and N,O-Dicarboxymethyl Chitosan Derivatives on Chlorophyll Photosynthesis and Fluorescence in Drought-Sensitive Maize.
Allelochemical Activity of Eugenol-Derived Coumarins on Lactuca sativa L.
Antifungal Activity of a Library of Aminothioxanthones.
Antifungal Activity of New Eugenol-Benzoxazole Hybrids against Candida spp.
Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation.
Characterization of antimicrobial and antioxidant performance of dihydroeugenol and its glycoside incorporated into whey protein isolate films.
Combining eugenol and dihydroeugenol with a piperazine moiety to create new antimicrobial agents that are effective against resistant species.
Coumarins as Potential Antiprotozoal Agents: Biological Activities and Mechanism of Action.
Design, Synthesis and Pharmacological Evaluation of Novel Antiinflammatory and Analgesic O-Benzyloxime Compounds Derived From Natural Eugenol.
Design, Synthesis, Antimicrobial Evaluation and Studies of Eugenol-Sulfonamide Hybrids.
Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Eugenol Esters as Leishmanicidal Agents.
Dihydroeugenol derivatives associated with blue LED light: A different form to face multidrug resistant (MDR) bacteria.
Do chitosan and its derivatives have the same protective effect on drought-contrasting maize genotypes? An analysis of physiological and production processes.
Evaluation of antiplasmodial activity in silico and in vitro of N-acylhydrazone derivatives.
Exploring how structural changes to new Licarin A derivatives effects their bioactive properties against rapid growing mycobacteria and biofilm formation.
From Antibacterial to Antitumour Agents: A Brief Review on The Chemical and Medicinal Aspects of Sulfonamides.
Glucosyl-1,2,3-triazoles derived from eugenol and analogues: Synthesis, anti- Candida activity, and molecular modeling studies in CYP-51.
In silico evaluation and in vitro growth inhibition of Plasmodium falciparum by natural amides and synthetic analogs.
In vitro and in silico antibacterial evaluation of coumarin derivatives against MDR strains of Staphylococcus aureus and Escherichia coli.
In vitro and in silico evaluation of the schistosomicidal activity of eugenol derivatives using biochemical, molecular, and morphological tools.
In vitro and in vivo trypanocidal activities of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2 -cromen-2-one, a new synthetic coumarin of low cytotoxicity against mammalian cells.
Investigation of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-chromen-2-one as a promising coumarin compound for the development of a new and orally effective antileishmanial agent.
Leaf application of chitosan and physiological evaluation of maize hybrids contrasting for drought tolerance under water restriction.
Molecular docking, quorum quenching effect, antibiofilm activity and safety profile of silver-complexed sulfonamide on.
Natural and Semi-synthetic Licarins: Neolignans with Multi-functional Biological Properties.
New Antifungal Agents with Azole Moieties.
New eugenol glucoside-based derivative shows fungistatic and fungicidal activity against opportunistic Candida glabrata.
New miconazole-based azoles derived from eugenol show activity against Candida spp. and Cryptococcus gattii by inhibiting the fungal ergosterol biosynthesis.
Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line.
Photobiological effect of eugenol-derived 3-benzoylcoumarin associated with led lights against MDR microorganisms.
Physicochemical characterization of chitosan and its effects on early growth, cell cycle and root anatomy of transgenic and non-transgenic maize hybrids.
Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach.
Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos.
Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors.
Synthesis and antimicrobial activity of molecular hybrids based on eugenol and chloramphenicol pharmacophores.
Synthesis and antimicrobial activity of 6-triazolo-6-deoxy eugenol glucosides.
Synthesis and biological evaluation of new eugenol Mannich bases as promising antifungal agents.
Synthesis and Biological Evaluation of New Eugenol-Derived 1,2,3-Triazoles as Antimycobacterial Agents.
Synthesis and biological evaluation of novel piperidine-benzodioxole derivatives designed as potential leishmanicidal drug candidates.
Synthesis and evaluation of marine-inspired compounds result in hybrids with antitrypanosomal and antileishmanial activities.
Synthesis and in vitro evaluation of antifungal and cytotoxic activities of eugenol glycosides.
Synthesis and in vitro evaluation of leishmanicidal activity of 7-hydroxy-4-phenylcoumarin derivatives.
Synthesis and in vitro evaluation of peracetyl and deacetyl glycosides of eugenol, isoeugenol and dihydroeugenol acting against food-contaminating bacteria.
Synthesis and structural characterization of new benzylidene glycosides, cytotoxicity against cancer cell lines and molecular modeling studies.
Synthesis and Structure-Activity Relationship Studies of Novel Aryl Sulfonamides and Their Activity against Human Breast Cancer Cell Lines.
Synthesis of eugenol-derived glucosides and evaluation of their ability in inhibiting the angiotensin converting enzyme.
Synthesis of New Hybrid Derivatives from Metronidazole and Eugenol Analogues as Trypanocidal Agents.
Synthesis of piplartine analogs and preliminary findings on structure-antimicrobial activity relationship.
Synthesis, activity, and docking studies of eugenol-based glucosides as new agents against Candida sp.
Synthesis, activity, and molecular modeling studies of 1,2,3-triazole derivatives from natural phenylpropanoids as new trypanocidal agents.
Synthesis, chemical characterization and antimicrobial activity of new acylhydrazones derived from carbohydrates.
Synthesis, protease inhibition, and antileishmanial activity of new benzoxazoles derived from acetophenone or benzophenone and synthetic precursors.
Tagitinin F has anti-inflammatory, anti-nociceptive and anti-matrix metalloproteinase properties: An in silico, in vitro and in vivo study.
The foliar application of a mixture of semisynthetic chitosan derivatives induces tolerance to water deficit in maize, improving the antioxidant system and increasing photosynthesis and grain yield.
The relationship between the antimicrobial activity of eugenol and the LPETG peptide structure and associated analysis for docking purposes.

Capítulos de livros

“Utilização do eugenol e fenóis correlatos em síntese orgânica: relato de experiência na geração de diversidade molecular e novas substâncias bioativas” – Capítulo no livro: Química Orgânica Sintética – Brasil 2022, E-Papers/Faperj/SBQ
“Hipnoanalgésicos” – Capítulo no livro: Fundamentos de Química Farmacêutica Medicinal, Editora Manole, 2022.